11
Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T10708 | CCR1 antagonist 6 | CCR | |
CCR1 antagonist 6 is a CCR1 antagonist (IC50: 3 nM). | |||
T15253 | CCX354 | CCR1 antagonist 1,CCX-354,CCX 354 | CCR |
CCX354 (CCR1 antagonist 1) is a potent small molecule CCR1 antagonist with anti-inflammatory activity for the treatment of rheumatoid arthritis. | |||
T10709 | CCR1 antagonist 7 | CCR | |
CCR1 antagonist 7 (compound 16r) is an antagonist of chemokine receptor 1 (CCR1) with an IC 50 of 4 nM [1]. | |||
T14899 | CCR1 antagonist 8 | CCR | |
CCR1 antagonist 8, a third azaindazole series compound, is a CCR1 antagonist (IC50: 1.8 nM in Ca2+ flux assay). | |||
T10710 | CCR1 antagonist 9 | CCR | |
CCR1 antagonist 9 is an effective and selective CCR1 antagonist (IC50: 6.8 nM in calcium flux assay). | |||
T2375 | BX471 | BX 471,BX-471,ZK-811752 | CCR |
BX471 (BX 471) is a potent, selective non-peptide CCR1 antagonist. | |||
T28072L | MLN-3897 TFA | MLN-3897 TFA(1010731-97-1 Free base) | CCR |
MLN-3897 TFA is a potent CCR1 antagonist that inhibits the binding of 125I-MIP-1α to THP-1 cell membranes. | |||
T14845 | BX471 hydrochloride | ZK-811752 hydrochloride | Others |
BX471 hydrochloride (ZK-811752 hydrochloride) is a potent, selective non-peptide CCR1 antagonist (Ki: 1 nM for human CCR1). It shows 250-fold selectivity for CCR1 over CCR2, CCR5, and CXCR4. | |||
T28072 | MLN-3897 | AVE9897,AVE 9897,CCR1 antagonist 10,AVE-9897 | CCR |
MLN-3897 (CCR1 antagonist 10) is an orally active antagonist of CCR1 with a Ki of 2.3 nM for 125I-MIP-1α binding to THP-1 cell membranes. MLN-3897 inhibits Akt signaling and MM cell survival and proliferation. | |||
T68427 | MLN-3897 citrate | ||
MLN-3897 citrate is a C-C Motif Chemokine Receptor 1 (CCR1) antagonist potentially for the treatment of multiple sclerosis and rheumatoid arthritis. | |||
T73371 | BAY-3153 | ||
BAY-3153 is a selective CCR1 ( C-C motif chemokine receptor 1 ) antagonist (human IC 50 =3 nM ; rat IC 50 =11 nM ; mice IC 50 =81 nM) . |